GENETIC RISK FACTORS FOR CREUTZFELDT-JAKOB DISEASE

Genetic risk factors for Creutzfeldt-Jakob disease

Prion diseases are a group of fatal neurodegenerative disorders of mammals that share a central role for prion protein (PrP, gene PRNP) in their pathogenesis.Prions are infectious agents that account for the observed transmission of prion diseases between humans and animals in certain circumstances.The prion mechanism invokes a misfolded and multim

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D-Dimer Tests in the Emergency Department: Current Insights

Francesca Innocenti, Cristian Lazzari, Francesca Ricci, Elisa Paolucci, Ilya Agishev, Riccardo Pini Emergency Department High-Dependency Unit, Department of Clinical and Experimental Medicine, Careggi University Hospital, Florence, ItalyCorrespondence: Francesca Innocenti Lg.Brambilla 4, Florence, 50144, ItalyTel +39 333 9117845Email innocenti.fra6

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Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences ROS levels is unclear.Here we report that the mitochondrial fusion and cristae shape protein Opa1 requires mitochondrial ATP synthase oligomers to reduce ROS accumulation.In cells Dla Dzieci f

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